The most traded Healthcare ETFs

Invest in Healthcare ETFs with DEGIRO

Are you interested in the healthcare sector or do you think a Healthcare ETF could be a valuable addition to your portfolio? Investing in ETFs is a simple way to increase diversification and gain exposure to global markets. On our platform, you’ll find a wide range of Healthcare ETFs to choose from.

Not all Healthcare ETFs are the same. They can differ in fund size, price, risk level and underlying assets. Some focus on large pharmaceutical companies, while others target innovative biotech firms, medical technology providers or healthcare services businesses. Depending on the strategy, you can invest across the healthcare industry or focus on specific sub-sectors with higher growth potential, but can also involve higher volatility and risk.

Here are the most traded Healthcare ETFs by our clients.

ETF name	ISIN
iShares Healthcare Innovation UCITS ETF (Acc)	IE00BYZK4776
iShares S&P 500 Health Care Sector UCITS ETF (Dist)	IE00B43HR379
SPDR MSCI World Health Care UCITS ETF (Acc)	IE00BYTRRB94
SPDR S&P U.S. Health Care Select Sector UCITS ETF (Dist)	IE00BWBXM617
Amundi MSCI World Health Care UCITS ETF (Acc)	LU0533033238

Based on total number of trades on the DEGIRO platform from 01.01.25-31.12.25. Only ETFs with more than 100 transactions are considered. The information on this page is intended for informational purposes only and does not provide any recommendations or financial advice. Some ETFs may (temporarily) not be available on our platform due to regulatory reasons.

Investing in ETFs, accessible to everyone

Exchange-traded funds (ETFs) allow you to quickly build a diversified portfolio. We offer a wide range of ETFs trading on 19 major exchanges. Whether you want to invest in local ETFs or global ETFs, investing opportunities are abundant. For more than 1000 ETFs traded on Tradegate, you only pay a €1 handling fee.

With our low fees and wide trading possibilities, we make investing in ETFs accessible to everyone. See a complete overview of our unprecedented rates here.

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Selected ETFs

COMMISSION

€ 0

+

HANDLING

€ 1

Worldwide

COMMISSION

€ 2

+

HANDLING

€ 1

*Currency, connectivity or external product & spread costs may apply. Find out more on our fees page. The ETF Core Selection is subject to change.

Check out the most traded ETFs

These are the most traded ETFs in 2025 included in our Core Selection based on the total number of trades on our Irish platform.

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VANGUARD S&P 500 ETF

IE00B3XXRP09

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VANGUARD FTSE ALL-WLD UCI

IE00BK5BQT80

Desk globe showing world map placed in front of blue triangle shape

ISHARES CORE MSCI WORLD E

IE00B4L5Y983

Close-up of desk globe showing world map with blue background shape

VANGUARD S&P 500 ETF

IE00BFMXXD54

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What is an ETF?

ETFs, also known as trackers, are funds that follow the performance of an index, commodity, bond or composition of products. Unlike some other funds, ETFs are bought and sold on a stock exchange. Would you like to learn more about ETFs? Read our ETF article for all you need to know.

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Healthcare

The healthcare industry plays a vital role in modern economies, providing essential products and services that support quality of life and wellbeing. It includes pharmaceutical companies developing medicines, biotechnology firms working on cutting-edge therapies, medical device manufacturers, hospitals, insurers and healthcare technology providers.

Healthcare demand tends to remain stable regardless of economic cycles, as people continue to require treatments, diagnostics and care. At the same time, innovation in areas such as genomics, digital health and personalised medicine is creating new growth opportunities. A Healthcare ETF strategy allows you to gain diversified exposure to this broad sector without selecting individual stocks. While these ETFs can provide a mix of stability and growth, they are still subject to risks, including regulatory changes, pricing pressures and company-specific setbacks that can affect returns.

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Why invest in Healthcare ETFs?

The healthcare sector is often considered one of the most resilient parts of the global economy. Demand for medicines, treatments and medical services remains relatively consistent, even during periods of economic uncertainty, which can help stabilise portfolios. For this reason, many investors use Healthcare ETFs as a defensive allocation alongside more cyclical sectors.

At the same time, healthcare is also a source of innovation and growth. Advances in biotechnology, artificial intelligence, diagnostics and medical devices are transforming how diseases are prevented and treated. This creates opportunities for companies developing breakthrough therapies and technologies. By investing through Healthcare ETFs, you can participate in this growth without needing to analyse or select individual stocks.

Healthcare ETFs also provide instant diversification across multiple companies and sub-sectors within the healthcare industry. Some funds focus on established pharmaceutical giants, while others target high-growth biotech or specialised healthcare services. This flexibility allows you to choose an ETF that matches your risk tolerance, time horizon and investment strategy.

FAQs

What is a Healthcare ETF and how does it work?

A Healthcare ETF is an exchange-traded fund that tracks the performance of a basket of healthcare companies. These may include pharmaceutical, biotech, medical device and healthcare services firms. Like other ETFs, it trades on a stock exchange and can be bought or sold during market hours, offering liquidity and diversification in a single investment.

Which companies are included in Healthcare ETFs?

Healthcare ETFs typically include a mix of large, established companies and innovative growth firms. Examples often include global pharmaceutical leaders such as Johnson & Johnson, Pfizer, Eli Lilly and Novartis, biotechnology specialists like Amgen, Gilead Sciences and Moderna, as well as medical equipment and technology providers such as Abbott Laboratories, Medtronic and Thermo Fisher Scientific. Some funds may also include healthcare insurers and service providers. The exact holdings depend on the index the ETF tracks.

How do I invest in the healthcare sector?

You can invest in the healthcare sector through an online broker such as DEGIRO. Simply open an account, search for a healthcare ETF by name, ticker or ISIN, and place a buy order. Before investing, compare factors such as costs (TER), fund size, diversification and risk level to ensure the ETF fits your financial goals and time horizon.